C-terminal truncated forms of Met, the hepatocyte growth factor receptor.
نویسندگان
چکیده
منابع مشابه
Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor (c-met).
Hepatocyte growth factor (scatter factor) is an angiogenic growth factor that binds to its cellular transmembrane receptor, c-met. Both HGF and c-met are expressed by vascular smooth muscle and endothelial cells, where HGF may exert autocrine and paracrine effects. We have found that human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) release a soluble,...
متن کاملNeoexpression of the c-met/hepatocyte growth factor-scatter factor receptor gene in activated monocytes.
Hepatocyte growth factor-scatter factor (HGF-SF ) mediates mito-, moto-, and morphogenic effects through the MET receptor, a membrane bound tyrosine kinase. HGF-SF/MET signaling is mitogenic for a large number of epithelial and endothelial cells and activates organ regeneration. HGF-SF transcripts have been detected in various myeloid cell lines. Therefore, the potential role of HGF-SF/MET sign...
متن کاملExpression of hepatocyte growth factor receptor (c-met) mRNA in primary cultures of human hepatocytes.
Aim-To investigate the regulation of hepatocyte growth factor (HGF) receptor (c-met) gene expression in isolated primary human hepatocytes.Methods-Primary hepatocytes were maintained in monolayer culture for up to 72 hours in serum-free medium. They were treated with growth factors and the level of HGF, c-met and reduced glyceraldehyde-phosphate dehydrogenase mRNA expression determined by north...
متن کاملExpression and functional role of hepatocyte growth factor receptor (C-MET) during postnatal rat testis development.
The met protooncogene encodes the hepatocyte growth factor receptor (HGFR, c-met). C-met, a tyrosine kinase receptor protein, is widely expressed in different cell types including the male reproductive tract. As we recently demonstrated, both c-met messenger RNA and protein are expressed in prebuberal rat testis. The aim of this work was to detect the expression of c-met during postnatal testis...
متن کاملOverexpression of hepatocyte growth factor and its receptor c-Met in nasal polyps.
OBJECTIVES To investigate the expression and distribution of hepatocyte growth factor (HGF) and c-Met proteins in normal nasal mucosa and in nasal polyps and to evaluate the possible effects of HGF and c-Met on the development of nasal polyps. DESIGN Prospective study. SETTING Tertiary academic institution. PATIENTS Normal inferior turbinate mucosa was obtained from 20 patients undergoing...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1991
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.11.12.5954